https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20472 Wed 11 Apr 2018 18:26:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15146 Wed 11 Apr 2018 17:11:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15370 Wed 11 Apr 2018 15:40:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20396 Wed 11 Apr 2018 15:20:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14775 Wed 11 Apr 2018 14:43:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16778 Wed 11 Apr 2018 12:49:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22828 Wed 11 Apr 2018 12:09:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24148 Wed 11 Apr 2018 11:25:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9732 Wed 11 Apr 2018 11:20:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4380 Wed 11 Apr 2018 10:34:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15361 Wed 11 Apr 2018 09:51:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30572 Wed 10 Oct 2018 16:22:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45101 Wed 07 Feb 2024 17:04:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50708 Wed 02 Aug 2023 15:00:51 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35895 Tue 19 Jan 2021 18:44:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30240 EIG121) has been associated with breast and endometrial cancers, but its mechanism of action remains unknown. In a genome-wide search for tandem repeats, we found that EIG121 contains a short tandem repeat (STR) in its upstream regulatory region which has the potential to alter gene expression. The presence of this STR has not previously been analysed in relation to breast or endometrial cancer risk. Results: In this study, the lengths of this STR were determined by PCR, fragment analysis and sequencing using DNA from 223 breast cancer patients, 204 endometrial cancer patients and 220 healthy controls to determine if they were associated with the risk of developing breast or endometrial cancer. We found this repeat to be highly variable with the number of copies of the AG motif ranging from 27 to 72 and having a bimodal distribution. No statistically significant association was identified between the length of this STR and the risk of developing breast or endometrial cancer or age at diagnosis. Conclusions: The STR in the upstream regulatory region of EIG121 is highly polymorphic, but is not associated with the risk of developing breast or endometrial cancer in the cohorts analysed here. While this polymorphic STR in the regulatory region of EIG121 appears to have no impact on the risk of developing breast or endometrial cancer, its association with disease recurrence or overall survival remains to be determined.]]> Thu 28 Oct 2021 12:35:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36303 80%) for six of the 12 most common cancer types: breast, colorectum, kidney, lung, pancreas and uterus. The available hospital data covered more recent time periods. We have since obtained more recent cancer registry data, allowing us to further test the validity of hospital diagnosis records in identifying incident cases. Results: The more recent hospital diagnosis data were valid for identifying incident cases for the six cancer types, with sensitivities 81-94% and PPVs 86-96%. However, 2-10% of cases were identified >3 months after the registry's diagnosis date and detailed clinical cancer information was unavailable. The level of identification was generally higher for cases aged <80 years, those with known disease stage and cases living in higher socioeconomic areas. The inclusion of death records increased sensitivity for some cancer types, but requires caution due to potential false-positive cases. This study validates the use of hospital diagnosis records for identifying incident cancer cases.]]> Thu 13 Jan 2022 10:28:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24914 Thu 13 Aug 2020 08:45:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17107 Thu 07 Feb 2019 14:51:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32813 Mon 23 Sep 2019 12:29:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38225 Mon 16 Aug 2021 15:40:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37247 Mon 14 Sep 2020 13:45:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27874 Fri 23 Oct 2020 11:58:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34896 0.05). Our findings suggest that when making cancer treatment decisions, clinicians should consider offering patients and support persons written and online information, combined with two shorter consultations.]]> Fri 10 Mar 2023 17:39:19 AEDT ]]>